Medical Director, US Medical Affairs
Company: Dyne Therapeutics
Location: Waltham
Posted on: January 28, 2026
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Job Description:
Company Overview: Dyne Therapeutics is focused on delivering
functional improvement for people living with genetically driven
neuromuscular diseases. We are developing therapeutics that target
muscle and the central nervous system (CNS) to address the root
cause of disease. The company is advancing clinical programs for
myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy
(DMD), and preclinical programs for facioscapulohumeral muscular
dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to
deliver functional improvement for individuals, families and
communities. Learn more https://www.dyne-tx.com/ , and follow us on
X , LinkedIn and Facebook . Role Summary: The US Medical Director
of Medical Affairs leads Dyne’s medical strategy and execution
within the United States, focusing on launch readiness, US-specific
KOL engagement, congress planning and execution, and supports
real-world evidence (RWE) initiatives. This role ensures alignment
with global strategy while tailoring activities to US regulatory,
payer, and healthcare landscapes. This role leads efforts to
communicate and disseminate scientific and clinical information,
engage with medical professionals in the field and contribute to
the overall success of the company’s portfolio. The US Medical
Director collaborates closely with Global Medical Affairs, US
Commercial, Regulatory, Market Access, and Clinical teams to drive
successful product introduction and lifecycle management in the US
market. This role is located in our Waltham, MA office. Primary
Responsibilities Include: Develop and execute US Medical Affairs
strategy aligned with global objectives and US market needs Act as
point person for all US Medical Affairs launch readiness
activities, including working closely with global medical director
and scientific communications on development of scientific platform
development, local congress planning, and local medical education
programs Support congress strategy execution in the US, including
booth activities, symposia, and scientific presentations Work
closely and with the Head of the Medical Science Liaison (MSL) team
on US KOL engagement strategy: identify, map, and build
relationships with key US experts Support insight collection and
synthesis, and supporting the development of field material,
working with the MSL team Develop US Medical Affairs advisory board
strategy and organize and execute advisory boards and expert panels
Work collaboratively with HCP and Patient Marketing as well as
cross-functional stakeholders to integrate medical perspectives
into brand strategy, ensuring alignment with scientific and
commercial objectives Partner with Clinical Development and
Clinical Operations to support US trial site engagement and
recruitment strategies Working with the Global Medical Director,
identify opportunities to generate real-world evidence (RWE) and
phase IV data to address data gaps and support HCP and payer
treatment decisions Ensure compliance with US regulatory and legal
requirements for all medical activities Serve as subject matter
expert on neuromuscular diseases and Dyne’s therapeutic platforms
for US stakeholders Support the review and approval of externally
presented materials through the Medical Review committee and
Promotional Review Committee Act as a role model for integrity and
compliance in all interactions Education and Skills Requirements:
Doctorate degree (MD, PhD, PharmD) with experience in rare
diseases; neuromuscular experience preferred Minimum 8 years of
relevant experience in Medical Affairs within the US
pharmaceutical/biotech industry Proven ability to lead US launch
readiness and medical strategy execution Excellent communication
and relationship-building skills with US KOLs and cross-functional
teams Ability to interpret and communicate complex scientific data
to diverse audiences Effective communication skills (written,
verbal and presentation) Must be willing to travel up to 30%,
inclusive of overnight and occasional weekends to meet with
customers, internal stakeholders and attend relevant conferences
Candidates must be authorized to work in the U.S. Positive team
member who embodies Dyne’s Core Values Excitement about Dyne’s
vision and mission Experience managing direct reports MA Pay Range
$196,000 - $285,000 USD The pay range reflects the base pay range
Dyne reasonably expects to pay for this role at the time of
posting. Individual compensation depends on factors such as
education, experience, job-related knowledge, and demonstrated
skills. The statements contained herein reflect general details as
necessary to describe the principles functions for this job, the
level of knowledge and skill typically required, and the scope of
responsibility, but should not be considered an all-inclusive
listing of work requirements. Individuals may perform other duties
as assigned, including work in other functional areas to cover
absences or relief, to equalize peak work periods or otherwise
balance workload. Dyne Therapeutics is an equal opportunity
employer and will not discriminate against any employee or
applicant on the basis of age, color, disability, gender, national
origin, race, religion, sexual orientation, veteran status, or any
classification protected by federal, state, or local law.
Keywords: Dyne Therapeutics, Lawrence , Medical Director, US Medical Affairs, Healthcare , Waltham, Massachusetts
